Unraveling chromosome 22

Human chromosome 22.

The acrocentric chromosome 22, one of the shortest human chromosomes, carries about 52 000 kb of DNA. The short arm is made up essentially of heterochromatin and, as in other acrocentric chromosomes, it contains ribosomal RNA genes. Ten identified genes have been assigned to the long arm, of which four have already been cloned and documented (the cluster of lambda immunoglobulin genes, myoglobi...

The transcriptional activity of human Chromosome 22.

A DNA microarray representing nearly all of the unique sequences of human Chromosome 22 was constructed and used to measure global-transcriptional activity in placental poly(A)(+) RNA. We found that many of the known, related and predicted genes are expressed. More importantly, our study reveals twice as many transcribed bases as have been reported previously. Many of the newly discovered expre...

Chromosome 22 abnormalities in Ewing's sarcoma.

A child with disseminated Ewing's sarcoma underwent cytogenetic investigations which showed different structural rearrangements of chromosome 22 at diagnosis (?ring22), and at relapse [t(10;22)], but the classic translocation t(11;22) was not detectable. This case provides further evidence of the importance of chromosome 22 in this disease, while raising some questions about the central importa...

A linkage disequilibrium map of chromosome 22

Fractal Dimension of Human Chromosome 22

Based on complex genomic signal analysis, it has recently been reported that DNA sequences show large-scale regularities, at the scale of whole chromosomes. The paper shows that these long range correlations can also be found in a fractal-like structure of DNA genomic signals, as well as in their 1/f noise. Specifically, the paper studies the fractal dimension of DNA segments along homo sapiens...